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Scientific Publications

Access to site-specific Fc-cRGD peptide conjugates through streamlined expressed protein ligation.

Frutos S, Jordan JB, Bio MM, Muir TW, Thiel OR, Vila-Perelló M.

Org Biomol Chem. 2016 Oct 12;14(40):9549-9553. doi: 10.1039/c6ob01833e. 


Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells

Barbuto S, Idoyaga J, Vila-Perelló M, Longhi MP, Breton G, Steinman RM, Muir TW.

Nat Chem Biol. 2013 Apr;9(4):250-6. doi: 10.1038/nchembio.1186.


Streamlined expressed protein ligation using split inteins

Vila-Perelló M, Liu Z, Shah NH, Willis JA, Idoyaga J, Muir TW.

J Am Chem Soc. 2013 Jan 9;135(1):286-92. doi: 10.1021/ja309126m.


Ultrafast protein splicing is common among cyanobacterial split inteins: implications for protein engineering

Shah NH, Dann GP, Vila-Perelló M, Liu Z, Muir TW.

J Am Chem Soc. 2012 Jul 18;134(28):11338-41. doi: 10.1021/ja303226x.


Kinetic control of one-pot trans-splicing reactions by using a wild-type and designed split intein

Shah NH, Vila-Perelló M, Muir TW.

Angew Chem Int Ed Engl. 2011 Jul 11;50(29):6511-5. doi: 10.1002/anie.201102909.


Branched intermediate formation stimulates peptide bond cleavage in protein splicing

Frutos S, Goger M, Giovani B, Cowburn D, Muir TW.

Nat Chem Bio. 2010 Jul; 6(7):527-33. doi:10.1038/nchembio.371.


Biological applications of protein splicing

Vila-Perelló M, Muir TW.

Cell. 2010 Oct 15;143(2):191-200. doi: 10.1016/j.cell.2010.09.031.